Elin Törnquist

My name is Elin Törnquist and I studied Engineering Physics at Lund University of Engineering, specializing in Biomedical Engineering, before starting a PhD with the Biomechanics Group where I did my MSc thesis project. In the project, I studied the microstructure in cortical bone by analysing X-ray microtomography images. The aim of the project was to analyse the relationship between cortical microstructure and crack propagation. Using K-means clustering I segmented out Haversian canals and osteons for analysis of porosity, distribution, and orientation. Based on the segmentations I created 2D models (based on fitting cylinders to the radii, lengths, and tilts of the microstructures) that were to be used for finite element modelling of crack propagation through the tissue in a PhD project.

The goal of my PhD project is to explore the potential of neutron tomographic imaging and small-angle scattering in studies of bone, in order to understand bone damage and fracture mechanisms on various hierarchical levels, and with osseointegration on implants in focus. The aim is to determine if neutron tomographic imaging is preferable to X-rays when studying bone ingrowth, damage and failure around metal implants; since the high-density contrast between metal and bone often results in significant artefacts in the close proximity of the implant it is not an optimal method. Furthermore, we aim to investigate if Small-Angle Neutron Scattering (SANS) can be used to obtain relevant information about the collagen phase in bone which is not well captured with the X-ray equivalent, SAXS.

Publications

Future behaviour of composite of bone and calcium sulfate/hydroxyapatite. J. Kok, E. Törnquist, D. B. Raina, S. Le Cann, V. Novak, A. Sirka, L. Lidgren, L. Grassi, H. Isaksson. Journal of the Mechanical Behavior of Biomedical Material (2022). http://dx.doi.org/10.1016/j.jmbbm.2022.105201

The Hydration State of Bone Tissue Affects Contrast in Neutron Tomographic Images. E. Törnquist, S. Le Cann, A. Tengattini, L. Helfen, J. Kok, S. A. Hall, H. Isaksson, Frontiers in Bioengineering and Biotechnology (2022).
https://doi.org/10.3389/fbioe.2022.911866

Dual modality neutron and X-ray tomography for enhanced image analysis of the bone-metal interface. E. Törnquist, S. Le Cann, E. Tudisco, A. Tengattini, E. Andò, N. Lenoir, J. Hektor, D. B. Raina, M. Tägil, S. A. Hall, H. Isaksson. Physics in Medicine and Biology (2021). https://doi.org/10.1088/1361-6560/ac02d4

A quality optimization approach to image Achilles tendon microstructure by phase-contrast enhanced synchrotron micro-tomography. M. Pierantoni, I. Silva Barreto, M. Hammerman, L. Verhoeven, E. Törnquist, V. Novak, R. Mokso, P. Eliasson, H. Isaksson. Scientific Reports (2021). https://doi.org/10.1038/s41598-021-96589-w

Comparison of small-angle neutron and X-ray scattering for studying cortical bone nanostructure. Elin Törnquist, Luigi Gentile, Sylvain Prévost, Ana Diaz, Ulf Olsson, Hanna Isaksson. Scientific Reports (2020). https://doi.org/10.1038/s41598-020-71190-9

Spatio-temporal evolution of hydroxyapatite crystal thickness at the bone-implant interface. S. Le Cann, E. Törnquist, I. Silva Barreto, M. Fraulob, H. Albini Lomami, M. Verezhak, M. Guizar-Sicarios, H. Isaksson, G. Haïat. Acta Biomaterialia (2020). https://doi.org/10.1016/j.actbio.2020.09.021

Neutron microtomography to investigate the bone-implant interface – comparison with histological analysis. F. Guillaume, S. Le Cann, A. Tengattini, E. Törnquist, C. Falentin-Daudre, H. Albini-Lomami, Y. Petit, H. Isaksson, G. Haïat. Physics in Medicine and Biology (2020). https://doi.org/10.1088/1361-6560/abf603