Life Science

Life-science research theme covers the study of biological molecules, cells, tissues, and bio-based materials, with the aim of understanding how structure, interactions, and dynamics give rise to function. In this Theme, the research spans proteins, lipid membranes, soft tissues, and sustainable biomaterials, addressing key challenges in human health, environmental safety, and green technology. By resolving how complex biological systems assemble, respond to their environment, and evolve over time, the work supports advances in areas such as disease mechanisms, drug delivery, biomaterials design, and bio-based alternatives to fossil-derived materials—making it highly relevant to both academia and industry.

Neutron techniques play a central role in life-science research because they offer unique sensitivity to hydrogen. Many life-science systems are soft, hydrated, and heterogeneous, and neutrons allow these to be studied under realistic, near-physiological conditions. Methods such as small-angle neutron scattering, neutron reflectometry, spectroscopy, and imaging provide access to structures and dynamics across multiple length and time scales that are difficult or impossible to probe with other techniques alone.

A key strength of neutron scattering is the possibility of contrast variation, which makes it possible to selectively highlight specific components—such as proteins, lipids, water, or additives—within complex multicomponent systems. This enables detailed studies of protein–membrane interactions, self-assembly processes, water transport, and soft-tissue structure, often in direct complement to X-ray, microscopy, and simulation approaches. Together, these capabilities make neutron methods essential for advancing life-science research and for developing new materials, therapies, and technologies inspired by biological systems.

Projects

A Multimodal Lens on Protein Assembly: From Silk to Seeds

PhD student: Juanita Francis, Lund University

Self-assembly of fluorocarbon amphiphiles and their interactions at interfaces with a seed protein

PhD: Njelama Sanga, Uppsala University (2025)

Neutron scattering studies of assembly, swelling and phonon transport of nanocellulose-based materials

PhD: Agnes Åhl, Stockholm University (2025)

Combining Low Resolution, High Resolution, Functional, and Simulation Techniques: In the Study of Pentameric Ligand-Gated Ion Channels

PhD: Marie Lycksell, Stockholm University (2022)

Small-Angle Scattering as a Tool to Study Protein Structure and Interactions

PhD: Zuzanna Pietras, Linköping University (2022)

Bone Structure Characterisation Using Neutron Scattering Techniques

PhD: Elin Törnquist, Lund University (2021)

Grazing Incidence Small Angle Neutron Scattering as a Tool to Study Curved Biomembranes on Nanostructured Surfaces

PhD: Karolina Mothander, Lund University (2021)

Alpha-Synuclein: Amyloid Fibrils and Interactions with Lipid Membranes

PhD: Marija Dubackic, Lund University (2021)

Polymorphs, Phase Behaviour and Dynamics of Amphiphiles

PhD student: Emil Gustafsson, Uppsala University

Neutron scattering of soft tissues to unravel musculoskeletal structure and fluid distribution during loading in health and disease

PhD Student: Tobias Wrammerfors, Lund University

Influence of intestinal colloidal structures and self-assembly on lipid-based formulations for enhancing peptide drug bioavailability

PhD student: Shahina Akter, Uppsala University

The role of water networks, hydrogen bonding, and protein dynamics inbiological energy conversion reactions studied by neutron scattering

PhD student: Nicholas Croy, Uppsala University

Characterization of water transport in lignocellulosic systems

PhD student: Hanno Holzinger, KTH Royal Institute of Technology

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