This project will focus on understanding how intestinal colloidal structures and lipid self-assembly influence the performance of lipid-based formulations designed to enhance peptide drug bioavailability. Lipid-based systems form complex nanoscale structures under gastrointestinal conditions, and these structures strongly affect peptide solubilisation, stability, and permeability. By clarifying these relationships, the project aims to provide a more robust scientific foundation for the development of effective oral peptide therapeutics.
The work will begin with the development of a hybrid analytical framework that combines small-angle neutron scattering with advanced simulation methods. SANS will be used to probe the nanostructure of intestinal colloids and lipid-rich aqueous formulations under physiologically relevant conditions, while molecular simulations will be employed to explore self-assembly pathways, structural transitions, and interactions between lipids, peptides, and excipients. Together, these approaches will enable detailed interpretation of how formulation components organise and evolve over time.
By integrating neutron scattering experiments with computational modelling, the project aims to deliver new insight into the structural and dynamical constraints governing oral peptide delivery. The findings are expected to support improved formulation strategies, reduce variability associated with permeability enhancers, and contribute to the rational design of next-generation lipid-based systems for peptide drugs.